diff --git a/lib/env_dpdk/init.c b/lib/env_dpdk/init.c
index 948d98105c..c3ceff29af 100644
--- a/lib/env_dpdk/init.c
+++ b/lib/env_dpdk/init.c
@@ -280,8 +280,13 @@ spdk_build_eal_cmdline(const struct spdk_env_opts *opts)
 			return -1;
 		}
 
-		/* set the base virtual address */
-		args = spdk_push_arg(args, &argcount, _sprintf_alloc("--base-virtaddr=0x1000000000"));
+		/* Set the base virtual address - it must be an address that is not in the
+		 * ASAN shadow region, otherwise ASAN-enabled builds will ignore the
+		 * mmap hint.
+		 *
+		 * Ref: https://github.com/google/sanitizers/wiki/AddressSanitizerAlgorithm
+		 */
+		args = spdk_push_arg(args, &argcount, _sprintf_alloc("--base-virtaddr=0x200000000000"));
 		if (args == NULL) {
 			return -1;
 		}
diff --git a/test/common/autotest_common.sh b/test/common/autotest_common.sh
index 252a20bf8d..d534c0cb6a 100755
--- a/test/common/autotest_common.sh
+++ b/test/common/autotest_common.sh
@@ -367,9 +367,8 @@ function rbd_cleanup() {
 
 function start_stub() {
 	# Disable ASLR for multi-process testing.  SPDK does support using DPDK multi-process,
-	# but ASAN instrumentation will result in mmap hints in our specified virt address
-	# region getting ignored.   We will reenable it again after multi-process testing
-	# is complete in kill_stub()
+	# but ASLR can still be unreliable in some cases.
+	# We will reenable it again after multi-process testing is complete in kill_stub()
 	echo 0 > /proc/sys/kernel/randomize_va_space
 	$rootdir/test/app/stub/stub $1 &
 	stubpid=$!